134 Large antiviral polyamide-DNA interactions

Project work NANOFLAKES Interactions with surfaces 134 . 114 Anna

Antiviral and Cellular Metabolism Interactions

6 Brenda I. Hernandez-Santiago, Judy S. Mathew, Kim L. Rapp, 7 Jason P. Grier, and Raymond F. Schinazi* 8 9 Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory School of 10 Medicine/Veterans Affair Medical Center, Decatur, GA 30033, USA 11 12 13

Polyamide platinum anticancer complexes designed to target specific DNA sequences.

Two new platinum complexes, trans-chlorodiammine[N-(2-aminoethyl)-4-[4-(N-methylimidazole-2-carboxamido)-N-methylpyrrole-2-carboxamido]-N-methylpyrrole-2-carboxamide]platinum(II) chloride (DJ1953-2) and trans-chlorodiammine[N-(6-aminohexyl)-4-[4-(N-methylimidazole-2-carboxamido)-N-methylpyrrole-2-carboxamido]-N-methylpyrrole-2-carboxamide]platinum(II) chloride (DJ1953-6) have been synthesized a...

DNA sequence recognition by an isopropyl substituted thiazole polyamide.

We have used DNA footprinting and fluorescence melting experiments to study the sequence-specific binding of a novel minor groove binding ligand (thiazotropsin A), containing an isopropyl substituted thiazole polyamide, to DNA. In one fragment, which contains every tetranucleotide sequence, sub-micromolar concentrations of the ligand generate a single footprint at the sequence ACTAGT. This sequ...

DNA sequence selectivity of hairpin polyamide turn units.

A class of hairpin polyamides linked by 3,4-diaminobutyric acid, resulting in a beta-amine residue at the turn unit, showed improved binding affinities relative to their alpha-amino-gamma-turn analogs for particular sequences. We incorporated beta-amino-gamma-turns in six-ring polyamides and determined whether there are any sequence preferences under the turn unit by quantitative footprinting t...